Rose hurt the toe during the first quarter Tuesday night in a win at Minnesota but stayed in the game. Rose scored a season-high 31 points against the Timberwolves and is averaging 20.7 points and 8.6 assists during the Bulls' 9-2 start.
"It's a pain tolerance thing. It's a sprain. He's gotten a lot of treatment. He usually responds very well to treatment," Bulls coach Tom Thibodeau said before the game.
"It's when the pain subsides when he can play."
Thibodeau said the Bulls hope Rose will be ready Friday night at Boston.
Chicago also was without injured guards Richard Hamilton (groin) and C.J. Watson (elbow) Wednesday night for its third game in three nights. Earlier Wednesday, the Bulls signed veteran guard Mike James for depth. John Lucas III was slated to start at point guard in Rose's place and starting shooting guard Ronnie Brewer can also move over and play that position.