Alzheimer's: Electricity Therapy May Keep Memories, Improve Learning, Could Help Patients

NEW YORK, N.Y. - People learned better when a key part of their brains got mild zaps of electricity, a finding that may someday help Alzheimer's patients keep more of their memories.

In a small but tantalizing study, participants played a video game in which they learned the locations of stores in a virtual city. They recalled the locations better if they learned them while receiving a painless boost from tiny electrodes buried deep inside their brains.

In the future, that strategy might help curb memory loss for people in the early stages of Alzheimer's disease, suggested Dr. Itzhak Fried, a neurosurgeon at the University of California, Los Angeles. But he cautioned that the results were preliminary.

Using implanted electrodes to treat brain disease is hardly new. Such "deep-brain stimulation" has been used for about a decade for Parkinson's disease and some other disorders. Researchers are also testing it for depression.

Some 80,000 or more people worldwide have had stimulation units implanted, mostly for Parkinson's.

Fried and colleagues reported the new work in Thursday's issue of the New England Journal of Medicine. It was financed by the federal government and the Dana Foundation.

"I think it's a terrific paper," said Dr. Andres Lozano, a professor of neurosurgery at the University of Toronto, who didn't participate in the work but is studying the approach in Alzheimer's patients. The new work shows stimulation can modify the workings of brain circuits that control memory in people, he said.

But like Fried, he cautioned that the research was still in the early stages.

"Whether it will translate into something useful, we do not know," he said, noting that years of additional study would be needed.

"You don't want to do brain surgery on people unless you have a pretty clear idea you're going to make them better," Lozano said. Deep-brain electrodes are implanted through holes drilled in the skull.

The study participants were seven epilepsy patients who had the electrodes implanted to help surgeons identify the source of their seizures. Fried and colleagues took advantage of that to stimulate a part of the brain that's key to learning. The patients could not feel the stimulation.

The patients played the video game on a laptop at their beds. Using a joystick, they took the role of taxi drivers in a small town consisting of four blocks by four blocks. They searched for passengers and dropped them off at any of six stores they were asked to find. The electrical stimulation was turned on while they learned the locations of some stores, but not others.

Testing showed that the stimulation made a difference. When given a store to find, the patients took a more direct route to it, and got there faster, if they had learned its location during a time of stimulation. When researchers looked at how much extra wandering they did beyond the shortest possible path, they found that stimulation reduced this excess by an average of 64 per cent.

The patients were tested only a few minutes after learning the store locations, so it's not yet clear how long the effect can last, Fried said. Researchers will also have to see if stimulation helps for other kinds of knowledge, he said.

———

Online:

New England Journal of Medicine: http://www.nejm.org

———

Malcolm Ritter can be followed at http://www.twitter.com/malcolmritter