Health officials have confirmed a 46-year-old man in Moose Jaw died in early February after taking the drug laced with PPMA.
PPMA is known as Dr. Death on the street and is more toxic than ecstasy but looks the same.
At least eight deaths in Alberta and five in British Columbia have been linked to tainted ecstasy in the last six months.
Saskatchewan's chief coroner Kent Stewart says people need to be aware that the tainted drug has made it into the province.
He says there's no way to know if ecstasy pills have been combined with PPMA or other dangerous substances.