Sedin was hurt when he was elbowed in the head by Chicago defenceman Duncan Keith late in the first period as the Blackhawks beat the Canucks 2-1 in overtime.
With 6:24 left in the first period, Keith hit Sedin in open ice and got his elbow up in the Swedish forward's face. Keith was given a two-minute minor penalty for elbowing on the play.
Sedin initially came right back out to participate in the power play with Keith in the penalty box, left for the dressing room shortly after. The Canucks announced he would not return for the remainder of the game.
"Everybody saw the head shot there, so (Sedin will be) re-evaluated tomorrow and I'll know more from there," Canucks coach Alain Vigneault said.
Vigneault called the hit a "deliberate, principal point of contact, everything you're trying to take out of the game."
Keith, the Blackhawks top defenceman at the 2010 Norris Trophy winner, received only a minor penalty on the play.
"I expected a major, and I got a minor, so we'll let the league deal with it," he added. "You saw the hit, you didn't see a puck near the hit, you guys make the judgment call on that and the league will do what they have to do."
"I'm not trying to hurt anybody," Keith said "I hope he's OK. He's one of their best players. He needs to be on the ice."
Rookie Andrew Shaw scored the winner 2:42 into overtime.
He was credited with deflecting Johnny Oduya's shot from the slot past Roberto Luongo. Oduya fired from between the circles after he trailed in late and took a feed from Dave Bolland on the left boards.
Patrick Kane scored his 20th goal in the second period for Chicago, which has won five straight and is 9-1-1 in its last 11 despite playing without captain Jonathan Toews.
Jannik Hansen scored in regulation for Vancouver — on the first shot of the game — to break a 15-game streak without a goal. The Canucks lost their second straight, and have won just one of their last five.
SABRES 3, CANADIENS 0
BUFFALO, N.Y. (AP) — Ryan Miller made 34 saves for a career-high sixth shutout this season and the Sabres continued their late-season push for a playoff spot with a win over Montreal.
Cody Hodgson scored twice and Jason Pominville once to help the Sabres improve to 11-2-4 in their past 17 games and catch the eighth-place Washington Capitals in the Eastern Conference standings. Miller improved to 11-1-3 in his past 15 games, a stretch in which he's allowed only 29 goals.
The shutout was the 28th of Miller's career, and fifth in his past 23 games.
The Canadiens (28-33-9) blew a chance to move out of last place in the East, while losing in regulation for the first time in seven games (3-1-3). With little to lose, Canadiens coach Randy Cunneyworth pulled goalie Carey Price for an extra attacker with 4 minutes left.
RANGERS 2, RED WINGS 1, OT
NEW YORK (AP) — Ryan Callahan ripped a shot in off a goal post 2:42 into overtime to send injury-riddled Detroit to its sixth straight loss.
The Rangers turned up the heat in the extra session and finally got a puck past Ty Conklin, who was recalled from the minor leagues earlier Wednesday because of Detroit's injury woes. Callahan fired a shot from the slot for his 27th goal, making the New York captain a winner on his 27th birthday.
Henrik Lundqvist made 26 saves, and Brad Richards scored in the first period for the Rangers, who lead Pittsburgh by three points in the East. Pittsburgh has 10 games left and the Rangers have nine.
Henrik Zetterberg gave Detroit an early 1-0 lead, and Conklin made 32 saves, but the Red Wings had to settle for just one point. Detroit, 0-4-2 in its last six, moved into sole possession of fourth place in the West, one point ahead of Nashville.
HURRICANES 3, PANTHERS 1
RALEIGH, N.C. (AP) — Joni Pitkanen had a goal and an assist in his first game in three months, and Carolina snapped the Panthers' five-game winning streak.
Eric Staal had his second straight two-goal game — giving him a team-leading 23 — and Cam Ward made 30 saves to help the Hurricanes win their season-best fourth straight and earn points for the 14th time in 17 home games.
Tomas Fleischmann scored for the Southeast Division-leading Panthers, who had been on their longest winning streak since a club-record seven straight in 2008. They were denied their first season sweep in Raleigh.
Jose Theodore stopped 36 shots for Florida. He entered 4-0 this season against the Hurricanes.
DUCKS 4, BLUES 3
ANAHEIM, Calif. (AP) — Jason Blake scored the tiebreaking goal from behind the St. Louis net with 5:54 to play, and Anaheim rallied from a third-period deficit for a victory over the NHL-leading Blues.
Devante Smith-Pelly tied it earlier in the third period for the Ducks, who erased three St. Louis leads before Blake banked his seventh goal of the season off the skate of St. Louis defenceman Ian Cole. Jonas Hiller made 35 saves for Anaheim, which won five straight home games over St. Louis.
Cam Fowler and Nick Bonino also scored and captain Ryan Getzlaf had two assists for the Ducks, whose playoff hopes are essentially dead despite a strong second-half surge under new coach Bruce Boudreau.
Jaden Schwartz scored his second goal in his second NHL game, while captain David Backes and David Perron also scored for the first-place Blues in their first game since earning their 100th point and clinching their first playoff berth in three years last Saturday at Tampa Bay.