Students angry with the province's tuition hikes are going to work against the Liberals in 10 ridings the party barely won in the last election.
An election could happen anytime between this spring and late 2013.
The protest groups also plan to contact the largest donors to Premier Jean Charest's party and urge them to side with the students.
The Charest government is nearly doubling tuition fees over five years, to $3,800 per year, to bring them closer to the national average.
The government points out Quebec fees will still be among the lowest in the country. But students say the increase is happening too fast and will discourage people from pursuing a higher education.
The ridings targeted will see students hand out flyers and produce videos aimed at influencing public opinion.
Some of the ridings in question belong to heavy hitters in the Charest cabinet, including senior ministers Pierre Corbeil, Robert Dutil, Pierre Moreau and Monique Gagnon-Tremblay.
Another Quebec cabinet minister felt the students' anger this morning. Finance Minister Raymond Bachand had to be escorted out of Montreal city hall to avoid a student protest.