Rose was helped off the court late in Chicago's 103-91 playoff-opening victory over the Philadelphia 76ers on Saturday, a staggering blow for a team eyeing a championship run.
He scored 23 points and was playing more like the league's reigning MVP after missing 27 games because of injuries during the regular season, but his season came to an end as the Bulls were wrapping up an impressive win.
Rose crumbled to the ground after he drove the lane with about 1:20 left and the Bulls leading by 12. He was going for a layup when he came to a jump-stop and seemed to change his mind as the 76ers' Spencer Hawes and Lavoy Allen rotated over, passing off to a teammate before an awkward landing.
Team medical personnel immediately rushed out and tended to Rose for several minutes as he was writhing in pain near the baseline before helping him to the locker room. Rose was taken to the hospital, where MRI results confirmed the Bulls' worst fears.