Tigers, leopards and lions — more than two dozen — were loose before being hunted by sheriff's deputies.
While the slaughter was chilling, it was truly panic-inducing that an unstable owner had accumulated such a collection of dangerous animals.
Yet, by some estimates, there are thousands of tigers in captivity in American backyards — more than there are in the wild on the planet.
No one knows the number for certain because there's only scattered regulation for such pets. In fact, it's easier in some states to buy a tiger or lion from a breeder than it is to adopt a kitten from a shelter.
That's likely to change after the Zanesville stampede drew the attention of lawmakers around the country.
Legislation has been proposed in Congress that would ban private ownership of exotic cats. Ohio and other states are also looking to outlaw the animals or to keep them more tightly controlled.
One leader of the cat fight is actress and animal activist Tippi Hedren, best known for being terrorized by crows in Alfred Hitchcock's "The Birds."
Hedren has devoted much of her life to rescuing big cats at her Shambala Preserve north of Los Angeles, home to 53 seized or abandoned exotic cats, and she doesn't think they make good pets.
"It is the job of the predator to take out any old, sick or lame animal. What quality there makes for a good pet?" she asked. "If you get near its food, it will kill you."
The Zanesville animals may have forced the issue into the open, but it certainly isn't the first tragedy involving private cats.
Since 1990, 21 people, including five children, have been killed and 246 mauled, according to Big Cat Rescue in Tampa, Fla. Over that period, 254 cats have escaped and 143 have been killed.
There have been other federal laws proposed over the years, but most have failed.
Deputies shot nearly 50 wild animals freed on Oct. 18 at Muskingum County Animal Farm near Zanesville. Owner Terry Thompson opened their cages before committing suicide. Some believe it was one last act of retaliation against neighbours and authorities.
Reps. Howard "Buck" McKeon, R-Calif., and Loretta Sanchez, D-Calif., introduced the Big Cats and Public Safety Protection Act in February to require owners of tigers, lions, leopards, jaguars, cheetahs, panthers and other cats to register with the Department of Agriculture. Breeding would be banned except at accredited zoos and research and educational institutions. Penalties would include seizures, fines and jail.
"When accidents happen and these wild cats are released into our neighbourhoods, it causes panic, puts a strain on our local public safety responders and is extremely dangerous," McKeon said. He believes his bill will protect the public and the cats.
In Ohio, the state Senate recently passed a bill that would ban new ownership of lions, monkeys and other exotic animals, but allows current owners to keep their animals by obtaining a new state-issued permit by 2014 and meeting other strict conditions. It now goes to the House for consideration. Meanwhile, the Ohio Department of Agriculture announced Monday that it will return five surviving exotic animals, including two leopards, to Terry Thompson's widow, Marian Thompson.
Virginia, Arizona, Missouri, West Virginia, Tennessee, Indiana and Oklahoma are also considering exotic animal bans, according to Uappeal, an exotic animal lobbying group.
Currently, no single agency oversees how big cats are kept or treated. The Association of Zoos and Aquariums and USDA have some regulations. Some states, counties and cities have laws but many don't.
The federal bill has the backing of the International Fund for Animal Welfare, Born Free USA and other groups. But fans of the majestic beasts are in an uproar.
"All a ban law will do is force all these people to go underground and it will not help the animals at all," said Joseph Schreibvogel, president of the United States Zoological Association, which advocates on behalf of wild animal owners.
Lynn Culver, executive director of the Feline Conservation Federation, thinks the number of people who keep exotic cats as pets has been hugely inflated by proponents of the House bill. She says the bill will interfere with captive conservation and bring an end to circus and stage acts and cats in movies and on television.
"Independent zoos will be allowed to keep their existing animals but when the cats die, there will be zoos without big cats and that's tragic," Culver said. "Big cats are charismatic species, key to the success of any zoo or wildlife exhibit."
There are as many as 20,000 privately owned cats in the U.S. and about half are tigers, according to groups like the World Wildlife Fund and the AZA. The WWF says there are only 3,200 tigers left in the wild in Asia.
How the backyard population swelled while dwindling in nature is partly attributed to an unregulated industry, where a tiger cub can be bought for as little as $300 without any permit or registration.
Yet someone trying to adopt a kitten from a shelter might have to undergo a home inspection and have the pet sterilized, vaccinated, microchipped and licensed, said WWF senior policy adviser Leigh Henry.
In just months, a cub can weigh 400 pounds, cost $5,500 a year to feed and need room to roam. Defanging and declawing them doesn't make them safe, said AZA spokesman Steve Feldman.
Backyard breeders sell the big cats for pets, parts, game ranches, canned hunts, sideshows, photo booths and roadside attractions.
Overwhelmed pet owners often turn to sanctuaries to rescue them from mounting bills and potential danger.
Bobbi Brink, owner of Lions Tigers and Bears outside San Diego, started her sanctuary in 2002 after rescuing tigers Raja and Natasha from a Texas man who was ordered to upgrade their 6-foot-by-12-foot cages or find new homes for them.
She spent $250,000 on a tiger habitat with a pool and plenty of running room on 94 acres.
Brink recently said no to three 8-year-old Texas tigers seized from a man with dementia. She doesn't have room.
Accredited and established sanctuaries across the country are reaching capacity and some have been forced to close because donations dwindled during the recession. Accredited zoos will no longer take privately owned tigers. Their goal is species preservation and privately owned or "generic" tigers can't be traced to their wildly caught ancestors.
If the McKeon-Sanchez bill succeeds, some worry there will be a glut of displaced tigers and too many will be euthanized.