Guillen was asked about what the dust-up between Miami Heat star Dwyane Wade and coach Erik Spoelstra during Thursday's playoff game against Indiana.
Guillen, in his ninth season as a major league manager, said he has never had such a problem with a player.
"Have some respect," he said. "Why he said it, that's none of my business. If a player came out and said something, it would guarantee a fight."
Guillen didn't see the incident and said he doesn't know Wade or Spoelstra.