Toronto police say the fugitive squad arrested Kujtim (Timmy) Lika on Thursday morning through a joint investigation between city police and the Canada Border Services Agency.
Police say the 47-year-old Lika is wanted for alleged offences related to organized crime and conspiracy to distribute narcotics.
Lika is being held in Toronto where he will begin his extradition proceedings.
The "America's Most Wanted" website says the FBI identified Lika as an Albanian illegal immigrant from the former Yugoslavian republic of Macedonia.
Toronto police helped the FBI nab Lika's accomplice — Myfit (Mike) Dika — in 2010 and have been looking for Lika ever since.