The agency says Canadians made just over 807,000 overnight business trips outside the country in the quarter, up 4.0 per cent from the fourth quarter of 2010.
Of these trips, three-quarters, or 600,000, were to the United States, a 4.7 per cent increase.
Canadian overnight business travel overseas was up 2.0 per cent.
In the opposite direction, however, overnight business travel to Canada declined 2.1 per cent to just over 570,000 trips.
About 70 per cent of these trips were made by U.S. business people, although American business travel to Canada was down 2.1 per cent.
Foreign business travellers spent $588 million in Canada in the fourth quarter, while Canadian business people spent just over $1 billion abroad.
Canadians made 3.8 million overnight pleasure trips abroad in the fourth quarter, up 3.7 per cent from the same period in 2010. Foreign travel to Canada for pleasure, however, fell 6.6 per cent from the United States and 4.9 per cent from overseas nations.