06/09/2012 12:50 EDT | Updated 08/09/2012 05:12 EDT

Highway 401 crash sends 5 to hospital

Five people are in hospital after a fiery three-vehicle accident on Highway 401.

The crash involving a tractor-trailer and two other vehicles happened at the 401 and Dixie Road at around 5:30 a.m. ET.

It's not known what led to the crash, but Ontario Provincial Police Sgt. Dave Woodford said the tractor-trailer ended up in a ravine near a creek.

"The tractor-trailer did crash through the cement barrier, down the embankment towards the creek, and then automatically went up engulfed in flames," he said.

One passerby was taken to hospital with smoke inhalation.

Police shut down all eastbound 401 collector lanes at Dixie, but were reopened by mid-afternoon.

There was a small amount of diesel fuel spilled, and the Ministry of the Environment said that clean-up contractors were at the scene.

The crash was one of three major accidents since Friday.

A 41-year-old man died after his motorcycle struck the side of a car at Lawrence Avenue and Don Mills Road, and a 36-year-old man was sent to hospital after his motorcycle collided with a Jeep at St. Clair Avenue and Via Italia. There is no word on that man's condition.