The car crashed off of Steeles Avenue, west of Mavis Road in Brampton, around 2:30 a.m.
The four people who escaped the burning car climbed over a nearby fence and asked an area resident for help. All four were taken to hospital with back and neck injuries.
When firefighters and police arrived on the scene, the car was on fire. The vehicle was destroyed.
Peel Regional police are investigating the matter.