Arencibia, who had hit a home run in his three previous appearances, took a foul ball off the hand in the top of the second and didn't come to bat in the bottom half of the inning. Jeff Mathis came into the game for the Jays.
Arencibia was batting .242 with 16 home runs and 50 runs batted in on the season, with Wednesday his 81st appearance.
By the time the catcher departed, struggling starter Ricky Romero was already gone as well.
Romero gave up eight runs and six walks in just 1 1/3 innings of work, with Oakland eventually taking a 10-0 lead.
The left-hander, who started the season 8-1, is likely in line to lose for the sixth straight appearance.