"lt appears someone was in the wrong lane," Hamilton police Staff Sgt. Mike Worster told CBC Hamilton Saturday morning.
"The scene was pretty chaotic when officers arrived," Worster said. "There were a lot of injured parties all over the place and the cars were total write-offs. A lot of damage."
One man died at the scene of the crash at Jerseyville Road near Paddy Greene Road. Another man in the same vehicle died later in Hamilton General hospital.
Four people in the other vehicle were injured.
They were taken "all over," said Worster — McMaster, St. Joes and the General.
Two men were transported to Hamilton General Hospital with serious injuries. Another man was taken to St. Joseph’s Hospital with minor injuries. A 14-year-old girl also in the vehicle was transported to McMaster Children’s Hospital with minor injuries.
Worster said alcohol is not believed to be a factor in the crash, but speed might be.
Donna Stechey lives about a kilometre away from the crash site, and is on that stretch of road almost every day. She heard the sirens Friday night.
"When I heard the news, my heart sank," she told CBC Hamilton Saturday morning.
"It's a very dangerous road — it's not just that people go super fast, it's the twists and the blind turns."
She says she has seen the danger firsthand.
A couple of summers ago she says she was stopped on the side of the road with a friend while biking. They saw a truck come off a road to turn onto Jerseyville and miss a fire truck by inches.
"I wouldn't have really understood the blind spot unless I stood there that day. The air just came out of our bodies."
Worster said the road can be dangerous, as it's very hilly, curves, and doesn't have the best lighting. It's also bordered by conservation area, so deer wander through a lot.
"You really need to keep your speed down in that area," he said.
In a statement, Carmen D'Angelo, emergency services supervisor said:
"A Community Paramedic Response Unit was first to arrive on scene. This was followed by four Paramedic Transport Units from Hamilton and one Paramedic Transport Unit from Norfolk County. The Paramedics were assisted by Hamilton Fire Services from Ancaster."