The native of Surrey, B.C., is the lone Canadian entered in the men's 10-kilometre open-water competition.
The London course at Hyde Park's Serpentine water fowl pond has been good to Weinberger in the past.
The brash 22-year-old upstart beat the world-class field in the Olympic test event last summer.
But his coach Ron Jacks says about 18 in the field of 22 were high- calibre racers in that competition. He'll face a more challenging field Friday.
"In the Olympics, there will be 25 and they will all be of very good calibre," said Jacks. "That makes it a little bit tighter."
Jacks says he's tried to prepare Weinberger as best as possible.
"We try to put together what we think the race will go like," he said. "The Olympics is always different. You have to ready for everything. It's a contact sport, there's currents, there's things like that. Things happen."
If Weinberger makes the podium it will be Canada's third swimming medal of the Games after Ryan Cochrane won silver in the men's 1,500 freestyle and Brent Hayden won bronze in the 100 freestyle.
Canada also has medal chances in taekwondo Friday with Karine Sergerie of Sainte-Catherine, Que., in women's 67 kilograms and Sebastien Michaud of Quebec City in men's 80 kilograms.
Sergerie narrowly lost to Hwang Kyungseon of South Korea in the final at the Beijing Games, picking up silver in Canada's best Olympic finish ever in the sport.
Michaud was a bronze medallist at the 2007 and 2009 world championships.
Elsewhere, Canada will look to nudge its way onto the podium in the team synchronized swimming competition. The Canadians were fourth after Thursday's technical routine.
In men's freestyle wrestling, David Tremblay of Montreal competes in the 55-kilogram class while Matthew Gentry of Burnaby, B.C., wrestles at 74 kilograms.