Prude was injured in the third quarter of Edmonton's 28-20 win over Saskatchewan after lowering his head to make a hit on Roughriders receiver Terence Jeffers-Harris.
Prude remained motionless on the field for several minutes before medical personnel put a neck brace on him and placed the player on a stretcher and into an ambulance that was brought on to the field.
He was immediately taken to hospital for evaluation but the good news was Prude could be seen moving his feet while receiving medical treatment on the field and did move his arms as he was being placed into the ambulance.
"After a lengthy evaluation Friday night, Ronnie was released from the hospital around midnight," Eskimos general manager Eric Tillman said in a statement. "His playing status this week will be determined by our medical and coaching staffs.
"Football aside, we are very grateful to our team doctors and staff, the EMT's, and the medical staff at the University of Alberta Hospital for their combined professional expertise on Friday night."
The Eskimos host Montreal on Friday night.