The province says the Little Bow Continuing Care Centre in Carmangay is too old and underused to keep it open.
But families of the residents who are being moved are upset that they weren't consulted before they were given official notice last month.
NDP MLA David Eggen told the rally at Premier Alison Redford's constituency office that the decision compares to domestic abuse.
He says Albertans continue to be taken advantage of, yet still go back to the same government.
The crowd chanted and help up signs that read: "Save Little Bow" and "Seniors Have Rights Too."
Protesters also suggested other communities need to take notice because they could be next.
Opposition Wildrose MLA Ian Donovan, who represents the area, said the reasons the province gives for closing the centre keep changing, so he wonders if the move is a political rather than a structural issue.