People in the Garneau area reported hearing a large blasting noise at about 10 p.m.
The noise was from a bomb disposal robot that detonated a suspected pipe bomb that was in the in the alley behind the Safeway grocery store on 109 Street.
Police had received calls about a suspicious man at the Safeway earlier in the evening.
"The entire area was cordoned off and a nearby senior's building was also evacuated. Fortunately, no one was injured," said Dan Jones, an acting inspector for the Edmonton Police.