A fire at 417 Wilson Street, near Tisdale Avenue, started around 11:30 Thursday night, said Dave Christopher, spokesperson for the Hamilton fire department.
Christopher said crews worked well into the night.
"It's an older house and there were a number of different materials in the roof," he said. "The fire was knocked within an hour, but the crew was working on hot spots until 4:30 in the morning."
Christopher said the fire originated in an attached garage.
The house was being rented to a young couple who were not home at the time. There were no injuries.
Hamilton fire has been in touch with the owner who told them he visited the property a week ago and the home and garage were both secure.
Christopher expects that a Hamilton police arson investigator will be at the scene Friday morning.