The mixed martial arts star from Montreal had reconstructive knee surgery in January after tearing an anterior cruciate ligament and his internal meniscus during a wrestling training session last fall.
He says via Twitter that he's been given the all clear to resume competitive fighting.
There has been speculation he will make his comeback at UFC 154 on Nov. 17 in Montreal against interim champion Carlos Condit.
"I'm now medically cleared to compete in professional mixed martial arts events," tweeted St-Pierre. "Rendez-vous le 17 novembre, @UFC 154, Montreal!!!"
As of Tuesday afternoon, the St-Pierre-Condit bout was not one of the confirmed fights for the Montreal card.
Condit defeated Nick Diaz on Feb. 4 to become interim champion during St-Pierre's medical absence.