Escobar had a go-ahead RBI double in the third. His homer against Sabathia in the sixth gave the Blue Jays the lead again and his two-run double off Joba Chamberlain in the ninth helped secure Toronto's first series win since July 27-29.
J.A. Happ (3-1) overcame a season-high five walks for the win and Casey Janssen pitched a perfect ninth for his 17th save.
Sabathia (13-4) was undefeated over his last nine starts against Toronto — 8-0 with a 2.48 ERA — since the beginning of his Cy Young Award season of 2007 with Cleveland.
WHITE SOX 8, ORIOLES 1
BALTIMORE (AP) — White Sox rookie Dylan Axelrod took a three-hitter into the eighth inning and Chicago spoiled the Baltimore debut of Joe Saunders, scoring seven runs off the left-hander.
Gordon Beckham had three hits and three RBIs to help Chicago snap a five-game road losing streak. Alexei Ramirez went 3 for 4 with two RBIs and scored twice for the White Sox, who will seek a split of the four-game series on Thursday.
Omar Quintanilla drove in the lone run for the Orioles, whose four-game winning streak ended. Baltimore remained 3 1/2 games behind the first-place New York Yankees in the AL East.
RAYS 8, RANGERS 4
ARLINGTON, Texas (AP) — Evan Longoria homered twice, Tampa Bay roughed up Matt Harrison and the Rays beat the Rangers to snap a four-game losing streak.
After dropping the last two against the AL-West leading Rangers by one run, the Rays avoided the three-game sweep.
Harrison (15-8) allowed seven runs and 12 hits in 5 1-3 innings. He took a no-hitter into the seventh and permitted two hits in eight shutout innings in his last outing Friday night against Minnesota.
Tampa Bay had scored only 11 runs during their losing skid before breaking out for 16 hits against Texas.
Jake McGee (5-2) pitched a perfect sixth and five Tampa Bay relievers combined for 4 1-3 scoreless innings.
Josh Hamilton hit his 36th home run for Texas.
ATHLETICS 8, INDIANS 4
CLEVELAND (AP) — Josh Donaldson hit a three-run homer and five Athletics pitchers combined to beat the Indians.
Oakland took over the AL wild-card lead by one game over Baltimore with its 11th win in 13 games as Travis Blackley (5-3) gave up two runs over 5 2-3 innings. Ryan Cook got four outs for his 13th save.
Donaldson connected off rookie Corey Kluber (0-3) in the fourth inning for a 3-2 lead. Shoddy fielding by the Indians, losers of 13 of 14, helped the Athletics later extend the lead.
Jason Donald's homer in the third broke the Indians' 24-inning scoreless streak, but they fell to 5-26 since July 27.
ROYALS 1, TIGERS 0
KANSAS CITY, Mo. (AP) — Bruce Chen allowed four hits over a season-high eight innings, and Eric Hosmer's infield single in the fourth drove in the only run in the Royals' victory over the Tigers.
The last time Chen (10-10) lasted eight innings was last September, in his final two starts of the year. The veteran left-hander hadn't even gone seven in his past 11 outings.
Anibal Sanchez (2-4) matched him pitch for pitch most of the night, finally looking like the guy the Tigers thought they were acquiring in a July trade with Florida. Sanchez allowed seven hits in seven innings, but the RBI single off the fists by Hosmer proved to be decisive.
TWINS 10, MARINERS 0
MINNEAPOLIS (AP) — Samuel Deduno dominated for seven innings, Trevor Plouffe homered and had four RBIs, and the Twins beat the Mariners.
The normally wild Deduno (5-2) struck out a career-high nine with no walks to help the win for just the fourth time in their last 20 games.
After Trayvon Robinson singled with one out in the first inning, Deduno retired the next 18 Seattle hitters, all but one on groundballs or strikeouts.
Plouffe gave the Twins a 5-0 lead in the fourth with his 20th home run and first since returning on Aug. 13 after missing 21 games with a sore thumb.
Jason Vargas (13-9) failed to finish five innings for his second straight start. He allowed six runs on eight hits over 4 2-3 innings.
ANGELS 10, RED SOX 3
ANAHEIM, Calif. (AP) — Kendrys Morales and Chris Iannetta hit early two-run homers, C.J. Wilson snapped his 11-start winless skid and the Angels jumped all over new Boston starter Zach Stewart.
Torii Hunter, Alberto Callaspo and Erick Aybar all contributed run-scoring doubles during the three innings pitched by Stewart (0-1), who yielded 10 hits and fell behind 9-1 in a horrific Red Sox debut. Five Angels had multihit games, led by Hunter's 3-for-4 effort with two RBIs.
Wilson (10-9) got plenty of help in his first victory since June 26, ending a dismaying two-month stretch of futility by the Angels' $77.5-million left-hander.