The B.C. resident was travelling south at around 4.30 a.m. PT driving an older model Chrysler when he clipped the paramedic's northbound GMC Sierra pick-up truck near Salmon Valley Bridge.
The unidentified man then lost control of the car, which flipped over and tumbled off the highway. He was thrown from the vehicle and pronounced dead at the scene.
The paramedic was taken to University Hospital of Northern B.C. but was uninjured and is expected to be released.
Staff Sgt. Pat McTiernan says the Chrysler driver may have been driving erratically and alcohol, lack of a seatbelt and speed are being considered as contributing factors.
After closing Highway 97 as a result of the collision, police have now re-opened the highway to traffic in both directions. The vehicles involved in the collision have been recovered and the scene has been cleared.
Anyone who witnessed the crash or might have seen either vehicle before the collision is asked to contact the Prince George Traffic Services Unit on 250-649-4004.