The rally, called 'Action against Recent Sexual Assaults' is listed on Facebook. Organizers are encouraging people to join and "build resistance take up space" in an effort to reclaim the neighbourhood.
Police are currently investigating 10 cases of sexual assault that happened within the last two months.
Police believe the same man may have committed the assaults.
Police Const. Wendy Drummond told CBC News that the physical description of the suspect has remained consistent with each case: a black male with a heavy build, who is reported to be five-foot-10 to six feet tall.
Assaults began near Spadina Avenue and College Street and are believed to be linked to the latest slew of attacks near Bloor Street West and Christie Street.
Victims reported being approached from behind before being assaulted.
The rally will begin in Christie Pits Park at 7 p.m. and continue with a march through the neighbourhood.
Anyone with information related to these assaults is asked to call police at 416-808-7474 or Crime Stoppers anonymously at 416-222-TIPS (8477).