Running back Jimmy Hill added a touchdown on 15 carriers for 125 yards as the defending Vanier Cup champions improved to 2-0.
Kasean Davis-Reynolds rushed six times for 93 yards and touchdown, Wayne Moore chipped in with 11 carries for 67 yards and a score, while Sebastian Gladman-Saltarelli rounded out McMaster's ground assault with nine carriers for 48 yards and a TD.
Dahlin Brooks, Brad Fochesato and Tyler Loveday caught touchdown passes for the Marauders, while backup quarterback Marshall Ferguson was 8-of-11 passing for 129 yards and a TD.
Elsewhere in the CIS it was: No. 5 Western 62, Toronto 7; No. 10 Manitoba 31, No. 8 Saskatchewan 28; No. 9 Acadia 21, Saint Mary's 16; and York 47, Ottawa 36; No. 2 Rouge et Or 28, Gaiters 22; Gryphons' 28, No. 7 Lancers 9; and No. 6 Golden Gaels 42, Golden Hawks 16.
At Waterloo, Ont., the Marauders and Warriors were tied 7-7 after the first quarter before McMaster exploded for 37 points in the second to lead 44-7 at halftime.
After Waterloo conceded a safety to hand McMaster a 9-7 lead, Quinlan ran in from a yard out to make it 16-7.
Marauders linebacker Nicholas Shorthill followed that up by returning a Jamie Cook pass 30 yards for another TD. Quinlan then hooked up with Loveday and Brooks less than five minutes apart to make it 37-7. Davis added a 45-yard touchdown run with 12 seconds left in the half.
Cook finished the day 14-of-22 for 130 yards, a touchdown and two interceptions for Waterloo (0-2).
Nick Anapolsky and Paul Cecile caught TDs for the Warriors, while Ryan Di Risio added the other on the ground.
No. 5 Mustangs 62, Varsity Blues 7
At Toronto, Donnie Marshall threw for 202 yards and two touchdown as Western (2-0) pummelled the Varsity Blues (1-1).
Western running back Garret Sanvido added 103 yards and two TDs on 14 carries.
No. 10 Bisons 31, No. 8 Huskies 28
At Winnipeg, Cam Clark threw for 317 yards and three touchdowns as the Bisons (2-0) upset Saskatchewan (1-1).
No. 9 Axemen 21, Huskies 16
At Wolfville, N.S., Kyle Graves threw for 363 yards and a touchdown to go along with one interception as Acadia (1-0) downed Saint Mary's (0-1).
Lions 47, Gee-Gees 36
At Toronto, Kyle Exume rushed for 180 yards and three touchdowns as York (1-1) defeated Ottawa (0-2). Lions quarterback Myles Gibbons was 23-of-39 passing for 341 yards, a touchdown and two interceptions. He also added two TDs on the ground.
No. 2 Rouge et Or 28, Gaiters 22
At Lennoxville, Que., Pascal Lochard 7-yard touchdown run in the third quarter tied the game and Boris Bede kicked a 41-yard field goal to pull ahead for good as Laval (2-0) rallied to avoid an upset against Bishop's (0-2).
Gryphons' 28, No. 7 Lancers 9
At Windsor, Ont., Daniel Ferraro kicked four field goals as Guelph (1-1) upset the University of Windsor Lancers (1-1).
No. 6 Golden Gaels 42, Golden Hawks 16
At Waterloo, Ont., Justin Chapdelaine caught 182 yards and one touchdown as Queen's (2-0) spoiled the homer opener for Laurier (0-2).