Toronto police say they were called to the scene of a collision on Marlee Avenue at Glengrove Avenue at 8:42 a.m.
According to police, the motorcycle was heading north on Marlee Avenue when it was struck by a pickup truck moving west on Glengrove Avenue.
The motorcycle driver died at the scene. There were no other injuries.
Police say the victim is a 24-year-old male. His name has not been released.
The collision remains under investigation. Marlee Avenue was closed for several hours between Glencairn and Coldstream avenues that morning.