A spokesman for the unit said around 10 investigators from the department's Hammer Squad were looking for signs of illegal activity.
Squad members interviewed witnesses during the operation. There was no word of any immediate arrests.
Richard Fahey, the hospital's public affairs director, said investigators came to the offices at 8 a.m. requesting information related to the awarding of the contract for a new super hospital being built in a public private partnership.
"The MUHC is fully collaborating with the investigators and we do not have any further comment at this stage," he told reporters as he read a brief statement.
Quebec introduced Operation Hammer in late 2009 amid a flurry of corruption allegations that shocked the province.
The squad has been involved in a number of arrests since its inception.
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