The Special Investigations Unit says Toronto police were called to investigate a report involving a man with a knife on a TTC bus near Eglinton Avenue West and Dufferin Street.
When police arrived at the scene, they located a 24-year-old man.
The SIU says "there was an interaction" between police and the man, who subsequently fled the scene on foot. Police continued to pursue him.
The man was hit by a civilian vehicle at the intersection of Eglinton Avenue West and Northcliffe Boulevard.
He suffered a fractured right leg as a result of the collision and he "was apprehended and taken to Sunnybrook Hospital," according to the SIU.
Eight people are now investigating the incident. The SIU is asking for any witnesses to contact their lead investigator at 416-622-1957, or toll-free 1-800-787-8529, ext. 1957.
The SIU investigates all incidents involving police in which serious injury or death occur, or those in which allegations of sexual assault are raised.