A section of Highway 20 westbound was limited to a single lane, just past the exits for Décarie Boulevard north and the Champlain Bridge.
Truck driver Donald Cloutier said the lane closure could force him to take a 20 kilometre-long detour.
"As soon as you close one lane, we have to take detours all the time. Within a month, it's thousands and thousands of dollars that I lose," he said.
Gas station worker Donald Porter says drivers often take Saint Jacques Street to avoid traffic when Highway 20 gets backed up.
He says he's expecting to see a lot more frustrated drivers as a result of this latest closure.
"They're not happy, they're not happy at all, at all, at all," said Porter.
Baie D'Urfé Mayor Maria Tutino says she's concerned about her community members having to spend hours on the road struck in traffic instead of at home with their families.
She says the latest closure underlines the need for a new commuter train line to the West Island.
"We don't have other alternatives. It's adding more stress and frustration to our citizens," said Tutino.
Transport Quebec said the latest closure is necessary to accommodate work on a nearby ramp.
The roadwork should wrap up in mid-November.