Police were called early Saturday morning to a residence in Montreal North.
A 47-year-old man was found dead outside his home on Leblanc Avenue near the Prieur Street East intersection.
Montreal Const. Anie Lemieux said the man was known to police.
Witnesses told police that they saw the suspects drive away.
Officers have not confirmed whether the shooting was linked to organized crime or street gang activity.
No arrests have been made.
Saturday's murder was the 30th homicide of the year, and the fifth in recent days.
Montreal police are still searching for a suspect from the daytime shooting of a 43-year-old man on Thursday afternoon.
The man was shot near the intersection of St-Laurent Boulevard and Fleury Street East in Ahuntsic.
Earlier Thursday morning the bodies of two homicide victims were found by firefighters following a major fire in Montreal's east-end.
After at least 100 firefighters brought the flames under control, crews discovered the bodies inside the rooming house.
On the same day, a 24-year-old man was shot and killed. His body was found in the Mercier district, inside his parked car, which had been set on fire.