It happened at about 10 a.m. local time near the Town of Snow Lake, which is located about 700 kilometres north of Winnipeg.
The RCMP said a call came in from a passenger on the aircraft, saying that the plane had crashed.
Emergency crews reached the scene about noon and found the plane in a bush area about 10 kilometres from the Snow Lake airport.
The plane left Snow Lake Airport this morning, it is unclear where it was heading at this point.
Chris Crepski, a spokesperson for the Transportation Safety Board, has confirmed there were nine people onboard the plane.
He also said the aircraft was a Cessna 208, also known as a Caravan, operated by Gogal Air Service.
The survivors have serious injuries and rescuers are working to get them to hospital, the RCMP said. However, the remoteness of the crash along with bad weather are hampering rescue efforts.
RCMP spokesperson Line Karpish said rescuers have had trouble getting to the site.
"The plane basically crashed in a highly bushed area north of the airport," said Karpish. "Getting to the crash site has required that it be done by snowmobile."
It's not known if weather was a factor but Clarence Fisher, he Mayor of Snow Lake, told CBC News that the area was very cloudy Sunday morning.
"There are rescue personnel on the scene and they are trying to get them to the Snow Lake Hospital, or get them prepared to be medevaced out, if that's what needs to happen," said Fisher. "At this point, we're really unclear."
A Canadian Forces Search and Rescue Hercules plane has been dispatched to help, but the weather is limiting what it can do.
Police have not identified the person who died in the crash.
Gogal Air Services is a private aircraft company, which operates out of Snow Lake.