Jaynen Rissling had a goal and an assist for the Hitmen (16-5-3), who also beat the Hurricanes 3-2 on Tuesday night in Lethbridge to sweep the home-and-home series.
Alex Roach also scored for Calgary, which has won three straight games and eight of its past nine.
Axel Blomqvist and Tyler Wong scored for the Hurricanes (13-12-2), who have lost four straight games and five of their past six.
Chris Driedger only had to make 14 saves for the win as Ty Rimmer stopped 46 shots in a losing cause.
Calgary went 1-for-2 on the power play while Lethbridge finished 1-for-7.
Rissling put the Hitmen up 1-0 with an unassisted goal at 7:18 of the second period before Blomqvist replied for the Hurricanes just under four minutes later.
Roach then scored for Calgary late in the second period, but Wong scored a power-play goal for Lethbridge at 15:05 of the third period to tie up the game once again.
The Hitmen outshot the Hurricanes 20-3 in the final period and that hard work paid off as Virtanen scored the winning goal in the game’s final minute.