Nalcor Energy says the province's Supreme Court ordered the injunction against members of the NunatuKavut Community Council, who represent Inuit-Metis from southern Labrador.
The company says the injunction allows it to continue work at the construction site of the project without interruption while allowing protesters to rally at a safe distance at least 50 metres away.
The NunatuKavut Community Council has picketed against the proposed hydroelectric project but has said it never blocked access to the construction zone.
It says the development impedes access to traditional native territory.
The provincial government says the project, which is expected to cost at least $7.4 billion, is needed to serve future energy needs.