Khairi, a 65-year-old Afghan immigrant, was found guilty in November of fatally stabbing and slashing the throat of his wife Randjida Khairi in March 2008. She was 53.
The second-degree murder conviction carries an automatic life sentence.
Khairi had told the court he acted in self-defence, alleging his wife tried to attack him with a knife.
The Crown argued that Khairi was angry with his wife of 30 years and their six children for adopting Western values after coming to Canada from Afghanistan in 2003.
Five of Khairi's six children were in the courtroom on Monday. Two of his daughters quietly sobbed during the sentencing. One left the courtroom, visibly distraught.
The defence says it will appeal the sentence.