One person was hit in Coquitlam at Schoolhouse and Brunette roads, suffering minor injuries.
At almost the same time, a disabled man was hit in Vancouver at Cambie and Hastings streets.
"I heard a screech, then I come around the corner because I knew it was a bad accident, then the first thing I see is a guy lying on the ground knocked off his mobility scooter," a witness told CBC News.
The man had been hit by a taxi and was taken to hospital with unknown injuries.
Then, two women were hit in Richmond, at Bridgeport Road and Sweden Way.
One of the women was taken to hospital in serious condition, the other is said to be in stable condition.
Earlier, another pedestrian was hit at East 1st Avenue and Renfrew Street and was taken to hospital with serious injuries.
All drivers stayed with their vehicles at the accident scenes.
Pedestrian collisions common
Police did not provide further details about the incidents, but a statement from the Vancouver Police Department did say the number of pedestrians struck in collisions was not unusual for this time of year.
"We get multiple pedestrians struck in Vancouver daily and have dozens of collisions that we attend. We currently have officers on scene at six different motor vehicle collisions of various types right now. Unfortunately we can not report them all," said the statement.
"If the collision involves serious or aggravating factors, or results in a fatality, the on-call media officer will get notified and activated by our Duty Officer and we would provide further information."
According statistics provided by the Vancouver Police Department, pedestrians make up 56 per cent of traffic fatalites. ICBC says pedestrian collisions jump by 80 per cent this time of year when compared with the summer months.
On Thursday police released video from the Surrey, B.C., intersection where two joggers were mowed down Monday night by a hit-and-run driver.
The suspect vehicle is described as a white SUV, which is seen in the video at about 7:50 p.m. PT turning left and plowing into the two joggers as they crossed the street.
Two women were killed and two other women were injured in three separate hit-run incidents in the Metro region since Sunday.