Just before 6 a.m. a Dodge Neon travelling south in the northbound lanes, collided with a Honda Accord.
The drivers of the cars, both males, were killed in the collision.
The accident happend between Aurora Road and Mulock Drive in Aurora.
Police say the driver of the Neon was a 25-year-old man from Markham. But they say it isn't clear why he was driving in the wrong direction.
The driver of the Accord was a 57-year-old man from Unionville.
No names have been released.