Jack Rodewald and Kyle Burroughs had the other goals for the Pats (13-20-4), who got 24 saves from Teagan Sacher.
Lane Scheidl chipped in with two assists.
Craig Leverton and Jaimen Yakubowski scored for the Hurricanes (17-16-5).
Ty Rimmer stopped 24 shots in taking the loss.
Regina finished the night 1-for-1 on the power play, while Lethbridge was scoreless in three opportunities.