Farouq el-Oqdah's resignation is the second such high profile move on Saturday. Earlier on the day, Vice-President Mahmoud Mekki resigned, saying he realized that politics did not suit his professional background as a judge.
The brief TV report did not say why el-Oqdah quit, but it ends days of media speculations about his intentions. Islamist President Mohammed Morsi and his Prime Minister Hesham Kandil met with el-Oqdah earlier this week in what media reports said was an attempt to dissuade him from leaving.
His departure comes at a time when Egypt's pound has been losing value against the U.S. dollar and the postponement of a deal with the IMF for a much needed loan of $4.8 billion.