Const. Randy Fincham says a man was rushed to hospital with serious injuries just before 7 a.m.
Officers found the victim when they responded to a call of a fight in a lane just off Granville Street (and Smithe.)
Fincham says three "people of interest" are being questioned by police.
Forensic identification officers are combing the scene.
Popular bars and dance clubs line the street where the man was shot, and police often shut the strip to traffic on weekend nights for the safety of revellers.