Durham Regional Police were called to the scene of a collision on Whites Road, south of Pickering Concession 3, around 11:30 p.m. on Saturday.
According to a police news release, it is believed that a southbound vehicle left the road for unknown reasons and rolled over over "numerous times."
The driver was ejected from the vehicle.
The victim is a 64-year-old Pickering man. His name has not been released.
Police continue to investigate the circumstances of the crash. It is not yet clear if speed or alcohol were factors.