The Burnaby, B.C. singer will emcee the upcoming awards on April 21 at the Brandt Centre in Regina, organizers announced Sunday night.
Bublé has sold about 30 million albums worldwide and is a multiple Grammy and Juno-winner. His most recent Juno win came in 2012, when his Christmas album captured the album of the year title.
"It's a huge honour to be the host of a show that has done so much for Canadian talent, including myself," Bublé, 37, said in a statement.
"I am going to do my very best to make it a great night."
Aside from his singing career, the singer does have some performing experience: in the past, he's hosted network TV specials during the holiday season and also appeared on Saturday Night Live in comedy sketches poking fun of himself and his music.
Juno organizers typically enlist top singers, comedians or actors to serve as host. Recent picks have included veteran actor William Shatner and rapper Drake.
This year's nominees will be announced on Feb. 19.