RCMP say they were called to the scene of a two-vehicle collision on Wednesday afternoon about 45 kilometres south of Conklin.
They say the 54-year-old driver of one vehicle died at the scene while the 39-year-old driver and 24-year-old passenger of the other vehicle were taken to hospital in critical condition.
Both were airlifted to Edmonton hospitals.
The highway was closed for several hours while police investigated.
They said highways in the area were covered in snow and ice, and people were warned to take caution while driving.
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