Ottawa announced last summer it would conduct the study, a decision that was lauded by opponents of the towering turbines.
The department says revisions to the plan were informed by more than 950 comments submitted by residents during a public consultation.
It says changes were made to the assessment of infrasound and a questionnaire to be administered by Statistics Canada.
Turbine opponents contend that exposure to low-frequency noise and vibrations from wind turbines _ in particular, inaudible infrasound _ can lead to sleep disorders, headaches, depression, anxiety and even blood pressure changes.
The $1.8-million study will initially focus on residents in 2,000 dwellings near eight to 12 wind-turbine installations.
There are about 140 such land-based wind farms in Canada, most of them in Ontario and Quebec.
The study is being conducted by a team of more than 25 experts in acoustics, health assessment and medicine, including four international advisers.
Results are expected in late 2014.