Police say they were called to the scene of the collision on Uxbridge Concession Road 7, south of Ravenshoe Road, just before 10 p.m. Friday.
Investigators have determined that a northbound snowmobile collided with a pickup truck that was plowing a driveway.
The man on the snowmobile was taken to a hospital in Uxbridge, where he succumbed to his injuries.
His name has not been released, but police say the deceased is a 46-year-old man from Udora, Ont.
Police are still investigating.