Environment Canada is forecasting 15 to 25 centimetres of snow will fall in most parts of New Brunswick on Wednesday.
Parts of southern New Brunswick may miss out on a large amount of snow, but will see a mix of snow, rain and freezing rain.
All schools in the Anglophone West, Anglophone North and Anglophone East districts are being closed ahead of the storm.
Anglophone South district schools in Sussex, Norton, Apahoqui and Belleisle are being closed, however the remainder of that district will remain open.
Most schools in Francophone South are being closed on Wednesday, except for schools in Saint John and the Kennebecasis Valley.
Francophone schools in the northwest were already scheduled to be closed on Wednesday for a professional development day. And francophone schools in the northeast will remain open because district officials say they are only expecting the storm to hit late in the day.
New Brunswick was hit hard by a snow and wind storm on Monday that at one point left more than 6,000 NB Power customers without electricity.