James also had seven assists in another big performance after seeing his franchise-record run of scoring at least 30 end at seven games the previous night in Atlanta.
Dwyane Wade added 17 points, and the Heat took control in the first half, sending the Bulls to their fifth loss in seven games on a night when the Derrick Rose recovery story took another twist.
Rose had to go into damage control mode after his older brother Reggie blasted the organization in an ESPNChicago.com article for not making a move before Thursday's trade deadline.
Nate Robinson scored 14 points, Carlos Boozer had 12 points and 11 rebounds and Joakim Noah added 11 points, eight rebounds and eight assists, but he also committed four of the Bulls' season-high 27 turnovers.
SPURS 116, CLIPPERS 90
LOS ANGELES (AP) — Tony Parker scored 31 points and San Antonio led all the way en route to its fifth straight victory and first over the Clippers this season.
The Spurs improved to an NBA-best 22-10 on the road, where they've also won five in a row.
Parker had seven assists and no turnovers in 28 minutes and Danny Green added 15 points. The West-leading Spurs tied their season-best with 59-per cent shooting, hit eight 3-pointers and made 22 of 28 free throws. They had lost both previous meetings with the Clippers in November.
Matt Barnes scored 18 points, Blake Griffin had 17 points and Jamal Crawford 15 points as the Clippers' four-game winning streak ended in their first game after the All-Star break.