The victim came forward to police on Friday, almost a week after the alleged assault took place.
Police say the man was out alone when he met the women at a nightclub near King Street and University Avenue.
At the end of the night, the women offered the man a drive home.
They parked just a few blocks away, and it is alleged that the man was sexually assaulted by all four women at that time.
He was then driven a short distance away and asked to leave, police say.
Investigators say the suspects were seen leaving the area in "a silver Honda SUV-type vehicle."
Police say the suspects were each wearing short, black dresses and high heels.
All four women are described as being Caucasian, between 30 and 36 years of age, each weighing 190-200 pounds and standing about five feet, four inches tall.
The driver of the vehicle had blond hair, wings tattooed on the back of her neck and spoke with an accent that was possibly British.
Another suspect had longer, dark hair with the bottom dyed red.