The series of rapid collisions occurred at about 7 p.m. Saturday, when police say the driver of a Dodge Durango left the eastbound lanes of Highway 401 at Kennedy Road.
Police allege the driver ran a red light and subsequently struck 37-year-old Henry Mejia, who witnesses say was thrown 30 metres through the air as a result of the collision.
Toronto police Const. Hugh Smith told reporters that the victim "didn't have any chance," as the cyclist was "right at that impact point" when he was struck. Mejia died at the scene.
Four other people, including an infant, were taken to hospital. One woman was taken to a local trauma centre with serious injuries.
The 46-year-old driver of the SUV was arrested at the scene.
Alvaro David faces seven charges, including impaired driving and dangerous driving causing death. He appeared in court on Sunday and has been remanded into custody.