Mario Chalmers and Chris Andersen each scored 15 for Miami, which improved to 36-4 at home — topping the 35-6 mark by the 2004-05 Heat.
Miami held Chicago without a 2-point basket for the first 16 minutes of the second half, with the Bulls relying almost exclusively on 3-pointers.
Carlos Boozer had 16 points and 20 rebounds for the Bulls, who snapped Miami's 27-game winning streak last month. Chicago finished with 29 field goals and 30 fouls, allowing the Heat to shoot a season-high 41 free throws.
The loss keeps Chicago in the No. 6 spot in the Eastern Conference. Miami has wrapped up home-court advantage throughout the playoffs.
LAKERS 91, SPURS 86
LOS ANGELES (AP) — Dwight Howard had 26 points and 17 rebounds, and Los Angeles rallied in the fourth quarter to beat San Antonio in its first game since losing Kobe Bryant for the season.
Steve Blake scored 23 points for the Lakers (44-37), who lead Utah (42-38) by 1 1/2 games for the eighth post-season spot in the West after their seventh win in eight games. Bryant limped off the Staples Center floor with a torn Achilles tendon Friday night.
Tim Duncan had 23 points and 10 rebounds for the Spurs, who have lost six straight road games.
San Antonio (58-22) is likely to finish second in the West behind Oklahoma City (59-21), which holds the tiebreaker.
NUGGETS 118, TRAIL BLAZERS 109
DENVER (AP) — Andre Iguodala scored 28 points and Denver beat short-handed Portland to set an NBA franchise record with its 55th win.
Rookie Evan Fournier added 24 points for the Nuggets, who also extended their franchise-best winning streak at home to 22 straight to move a game ahead of the Los Angeles Clippers and Memphis for the third seed in the West.
The Nuggets went 54-28 in both 1987-88 and 2008-09, when they reached the conference finals. They are 37-3 at home — also a team best since joining the NBA 37 years ago.
Rookie Damian Lillard led Portland with 30 points.
KNICKS 90, PACERS 80
NEW YORK (AP) — Carmelo Anthony scored 25 points and New York clinched the No. 2 seed in the East with a victory over Indiana — the Knicks' 15th win in the last 16 games.
Chris Copeland added 20 points and J.R. Smith had 15 for the Knicks, who will host seventh-seeded Boston next weekend. New York is guaranteed the home-court advantage for the first two rounds of the playoffs after finishing a distant second to Miami in the conference.
Lance Stephenson scored 22 points and West had 17 points and eight rebounds for the Pacers, who came into the game with a chance to catch the Knicks for second but settled for the No. 3 seed after fourth-place Brooklyn lost at Toronto.
RAPTORS 93, NETS 87
TORONTO (AP) — DeMar DeRozan scored 36 points, Rudy Gay had 26 points and 10 rebounds and Toronto never trailed in beating Brooklyn for its third straight victory.
Amir Johnson had 10 points and nine rebounds for the Raptors, who hadn't won three straight since a five-game winning streak from Feb. 8 to 19.
DeRozan scored 14 in the fourth quarter and finished 9-for-9 at the free throw line, converting a vital pair in the final 15 seconds.
Deron Williams scored 30 points, Brook Lopez had 16 and Andray Blatche 15 for the Nets, who will be the No. 4 seed in the East.
ROCKETS 121, KINGS 100
HOUSTON (AP) — James Harden had 29 points and nine assists, Omer Asik had 10 points and 12 rebounds and Houston cruised to a win over Sacramento in its regular-season home finale.
Jeremy Lin added 15 points for the Rockets, who've won nine of their last 12 home games heading into the playoffs.
The Rockets climbed to sixth place in the Western Conference. They have the same record as Golden State (45-35) but own the tiebreaker after winning the season series with the Warriors 3-1. Houston plays Phoenix on Monday and finishes the regular season against the Los Angeles Lakers on Wednesday.
John Salmons scored 14 points and Isaiah Thomas had 10 points and 10 assists for the Kings.
MAVERICKS 107, HORNETS 89
NEW ORLEANS (AP) — Shawn Marion had 21 points on 10-of-16 shooting and Dirk Nowitzki scored 19 to become the 17th NBA player to surpass 25,000 career points, leading Dallas past New Orleans.
Brandan Wright and Vince Carter added 16 points for Mavericks (40-40), who reached the .500 mark for the first time since they were 11-11 in mid-December. They had lost by double digits in their three previous chances to even their record.
Ryan Anderson led the cold-shooting Hornets with 20 points, but he was only 8-of-20 from the floor. Eric Gordon added 15 points, and Robin Lopez had 10 points and 13 rebounds. New Orleans shot 39.7 per cent in its final home game and trailed by as much as 27.
76ERS 91, CAVALIERS 77
PHILADELPHIA (AP) — Dorell Wright scored 15 points and Thaddeus Young had 14 points and nine rebounds to lead Philadelphia over Cleveland.
Spencer Hawes and Jrue Holiday each added 14 points for the 76ers, who raced to a 19-point lead in the first half and sent the Cavaliers to their fourth straight loss.
Tristan Thompson had 12 points and 12 rebounds for the Cavaliers. Kevin Jones had 11 points and 10 rebounds, while All-Star guard Kyrie Irving had only four points in 18 minutes.
The Sixers finished 23-18 at home and are 33-47 overall a year after winning 35 games and a round in the playoffs during the lockout-shortened season.