A CFL source requesting anonymity said Tuesday that Brohm has agreed to terms with the Hamilton Tiger-Cats and is expected to be on the field for the start of the club's mini-camp Wednesday.
Brohm, 27, was taken in the second round, 56th overall, by the Green Bay Packers in the 2008 NFL draft out of Louisville.
Buffalo signed Brohm off of Green Bay's practice roster in 2009. The native of Louisville, Ky., appeared in three games over two seasons with the Bills, completing 27-of-52 passes for 252 yards with five interceptions and no TDs.
Brohm spent parts of the 2011 and 2012 seasons with the Las Vegas Locomotives of the United Football League.