More than 700 people signed up for the popular 10-kilometre run on Monday alone, double the number for the same day last year, said organizer Jamie Pitblado.
"It's kind of what Vancouver is all about, we continually rally around causes," he said.
Meanwhile, more than 60 runners took to the streets in Abbotsford on Tuesday night to remember those hurt in Boston, including some who have run the iconic marathon before.
"One thing I remember the most was the spectators... and to see harm done to them breaks my heart," said Dan Stefanson, who ran the Boston Marathon last year.
U.S. investigators are trying to determine who was behind the twin blasts that killed three people and wounded more than 170 near the finish line of the Boston Marathon on Monday.
They may follow the example of Vancouver police, analyzing photographic evidence to track down who is responsible, said Grant Fredericks, a U.S. forensic video analyst.
There have been no claims of responsibility for the attack as yet.
In Vancouver, run organizers met with police and safety officials on Tuesday and said there are no plans to significantly increase levels of policing or fire along the route.
Organizers are asking runners to wear yellow and blue — the official colours of the Boston Marathon — to honour those killed and injured in Boston.